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<front>
<journal-meta>
<journal-id></journal-id>
<journal-title-group>
<journal-title>Journal for Reproducibility in
Neuroscience</journal-title>
</journal-title-group>
<issn publication-format="electronic">2670-3815</issn>
<publisher>
<publisher-name>Publishers of Trial and Error</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<title-group>
<article-title>Anticompulsive-like effect of nitric oxide synthase
inhibitors in marble-burying test</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Montezuma</surname>
<given-names>Karina</given-names>
</name>
<xref ref-type="aff" rid="aff-0"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Biojone</surname>
<given-names>Caroline</given-names>
</name>
<xref ref-type="aff" rid="aff-1"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Joca</surname>
<given-names>Samia</given-names>
</name>
<xref ref-type="aff" rid="aff-2"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Casarotto</surname>
<given-names>Plinio</given-names>
</name>
<xref ref-type="aff" rid="aff-1"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Guimarães</surname>
<given-names>Francisco Silveira</given-names>
</name>
<xref ref-type="aff" rid="aff-1"/>
</contrib>
<aff id="aff-0">
<institution-wrap>
<institution>Department of Pharmacology, School of Medicine of Ribeirão
Preto (FMRP), University of São Paulo, Ribeirão Preto, SP, Brazil
Department of Physics and Chemistry, School of Pharmaceutical Sciences
of Ribeirão Preto (FCFRP), University of São Paulo, Ribeirão Preto, SP,
Brazil</institution>
</institution-wrap>
</aff>
<aff id="aff-1">
<institution-wrap>
<institution>Department of Pharmacology, School of Medicine of Ribeirão
Preto (FMRP), University of São Paulo, Ribeirão Preto, SP,
Brazil</institution>
</institution-wrap>
</aff>
<aff id="aff-2">
<institution-wrap>
<institution>Department of Physics and Chemistry, School of
Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São
Paulo, Ribeirão Preto, SP, Brazil</institution>
</institution-wrap>
</aff>
</contrib-group>
<pub-date date-type="pub" publication-format="electronic">
<day>13</day>
<month>08</month>
<year>2020</year>
</pub-date>
<volume>1</volume>
<elocation-id>anticompulsive-like-effect</elocation-id>
<permissions>
<license license-type="CC-BY-NC" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/">
<license-p>Creative Commons Attribution-NonCommercial 4.0 International
License</license-p>
</license>
</permissions>
<self-uri xlink:href="https://jrn.trialanderror.org/pub/anticompulsive-like-effect">This pub is available from https://jrn.trialanderror.org/pub/anticompulsive-like-effect</self-uri>
</article-meta>
</front>
<body>
<sec id="abstract">
  <title><bold>Abstract</bold></title>
  <p>Nitric oxide synthase (NOS) inhibitors decrease marble burying
  behavior (MBB), and the effect of several compounds that also
  attenuate MBB (such as classical antidepressants) engages the
  nitrergic system. In the present study, we tested the effect of the
  NOS inhibitor aminoguanidine (AMG) in attenuating MBB. For comparative
  reasons, we also tested the effect of selective inhibitors of neuronal
  (NOS1) and inducible (NOS2) isoforms NPA and 1400W, respectively. Our
  results indicate that AMG and NPA, but not 1400W, reduced the number
  of buried marbles in the marble burying test (MBT), which is
  considered an anticompulsive-like effect. No effect of AMG in the
  anxiety- or locomotor-related parameters of the elevated plus maze was
  observed. Taken together, our data is consistent with the current
  literature that suggests that nitric oxide inhibitors, putatively
  acting through the neuronal isoform of the synthesis enzyme (NOS1),
  exhibit anticompulsive-like properties.</p>
  <p><bold>Keywords: </bold><italic>marble burying test, nitric oxide
  synthase inhibitors, elevated plus maze, anxiety, repetitive behavior,
  NOS</italic></p>
  <graphic id="nsl5ae8ux36" mimetype="image" mime-subtype="png" xlink:href="https://assets.pubpub.org/zqt0ujuz/image-61691161317092.png" />
  <p></p>
  <p></p>
  <graphic id="nrbree3j3bo" mimetype="image" mime-subtype="png" xlink:href="https://assets.pubpub.org/pzrlppew/image-71691160815460.png" />
  <p></p>
</sec>
<sec id="reviewers-comments">
  <title>Reviewer’s Comments</title>
  <p>[file element]</p>
  <p></p>
</sec>
<sec id="references">
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