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\hypersetup{
  pdftitle={Preprints: a tool and a vehicle towards greater reproducibility in the life sciences},
  pdfauthor={Iratxe Puebla},
  hidelinks,
  pdfcreator={LaTeX via pandoc}}

\title{Preprints: a tool and a vehicle towards greater reproducibility
in the life sciences}
\author{Iratxe Puebla}
\date{true}

\begin{document}
\maketitle

\hypertarget{abstract}{%
\section{\texorpdfstring{\textbf{Abstract}}{Abstract}}\label{abstract}}

We have seen a number of initiatives arise in recent years aiming to
tackle concerns around the reproducibility of published findings.
Researchers in the life sciences now have a number of tools at their
disposal to boost the reproducibility of their science and preprints
have emerged as an instrumental element within this toolkit. Preprints
broaden the when, by whom and how of the review and feedback on research
compared to the journal publication process, help address publication
bias, and can play an important role as a vehicle towards open science
practices. Preprints hold further untapped potential to close the gap
between discovery and dissemination, and to accelerate the path to a
more reproducible research ecosystem.

\textbf{Keywords: }\emph{preprints, reproducibility, open science,
publication bias, peer review}

\includegraphics{https://assets.pubpub.org/r7s03hja/image-31691157741605.png}

\includegraphics{https://assets.pubpub.org/pzrlppew/image-71691160815460.png}

\hypertarget{references}{%
\section{\texorpdfstring{\textbf{References}}{References}}\label{references}}

De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, et al.
Clinical Trial Registration: A Statement from the International
Committee of Medical Journal Editors. N Engl J Med. 2004 Sep
16;351(12):1250--1.

Ioannidis JPA. Why Most Published Research Findings Are False. PLOS Med.
2005 Aug 30;2(8):e124.

Nosek BA, Errington TM. Making sense of replications. eLife. 2017 Jan
19;6:e23383.

Bring structure to your research {[}Internet{]}. protocols.io. {[}cited
2020 Dec 3{]}. Available from: \url{https://www.protocols.io}

Nosek BA, Alter G, Banks GC, Borsboom D, Bowman SD, Breckler SJ, et al.
Promoting an open research culture. Science. 2015 Jun
26;348(6242):1422--5.

Library \textbar{} The EQUATOR Network {[}Internet{]}. {[}cited Dec
3{]}. Available from: \url{https://www.equator-network.org/library/}

Turner EH, Matthews AM, Linardatos E, Tell RA, Rosenthal R. Selective
Publication of Antidepressant Trials and Its Influence on Apparent
Efficacy. N Engl J Med. 2008 Jan 17;358(3):252--60.

Therapeutic fashion and publication bias: the case of anti-arrhythmic
drugs in heart attack. {[}Internet{]}. The James Lind Library. {[}cited
2020 Dec 3{]}. Available from:
\url{https://www.jameslindlibrary.org/articles/therapeutic-fashion-and-publication-bias-the-case-of-anti-arrhythmic-drugs-in-heart-attack/}

BBC Radio 4 - The Life Scientific, Ottoline Leyser on how plants decide
what to do {[}Internet{]}. BBC. {[}cited Dec 3{]}. Available from:
\url{https://www.bbc.co.uk/programmes/b08q5wxx}

D. Chambers C, Feredoes E, D. Muthukumaraswamy S, J. Etchells P, 1
Cardiff University Brain Research Imaging Centre, School of Psychology,
Cardiff University; Instead of ``playing the game'' it is time to change
the rules: Registered Reports at AIMS Neuroscience and beyond. AIMS
Neurosci. 2014;1(1):4--17.

Soderberg CK, Errington TM, Nosek BA. Credibility of preprints: an
interdisciplinary survey of researchers. R Soc Open Sci. 7(10):201520.

Beck J, Ferguson CA, Funk K, Hanson B, Harrison M, Ide-Smith M, et al.
Building trust in preprints: recommendations for servers and other
stakeholders {[}Internet{]}. OSF Preprints; 2020 Jul {[}cited 2020 Nov
6{]}. Available from: \url{https://osf.io/8dn4w/}

\end{document}
