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\hypersetup{
  pdftitle={Anticompulsive-like effect of nitric oxide synthase inhibitors in marble-burying test},
  pdfauthor={Karina Montezuma; Caroline Biojone; Samia Joca; Plinio Casarotto; Francisco Silveira Guimarães},
  hidelinks,
  pdfcreator={LaTeX via pandoc}}

\title{Anticompulsive-like effect of nitric oxide synthase inhibitors in
marble-burying test}
\author{Karina Montezuma \and Caroline Biojone \and Samia
Joca \and Plinio Casarotto \and Francisco Silveira Guimarães}
\date{true}

\begin{document}
\maketitle

\hypertarget{abstract}{%
\section{\texorpdfstring{\textbf{Abstract}}{Abstract}}\label{abstract}}

Nitric oxide synthase (NOS) inhibitors decrease marble burying behavior
(MBB), and the effect of several compounds that also attenuate MBB (such
as classical antidepressants) engages the nitrergic system. In the
present study, we tested the effect of the NOS inhibitor aminoguanidine
(AMG) in attenuating MBB. For comparative reasons, we also tested the
effect of selective inhibitors of neuronal (NOS1) and inducible (NOS2)
isoforms NPA and 1400W, respectively. Our results indicate that AMG and
NPA, but not 1400W, reduced the number of buried marbles in the marble
burying test (MBT), which is considered an anticompulsive-like effect.
No effect of AMG in the anxiety- or locomotor-related parameters of the
elevated plus maze was observed. Taken together, our data is consistent
with the current literature that suggests that nitric oxide inhibitors,
putatively acting through the neuronal isoform of the synthesis enzyme
(NOS1), exhibit anticompulsive-like properties.

\textbf{Keywords: }\emph{marble burying test, nitric oxide synthase
inhibitors, elevated plus maze, anxiety, repetitive behavior, NOS}

\includegraphics{https://assets.pubpub.org/zqt0ujuz/image-61691161317092.png}

\includegraphics{https://assets.pubpub.org/pzrlppew/image-71691160815460.png}

\hypertarget{reviewers-comments}{%
\section{Reviewer's Comments}\label{reviewers-comments}}

{[}file element{]}

\hypertarget{references}{%
\section{\texorpdfstring{\textbf{References}}{References}}\label{references}}

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\end{document}
